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This experiment was performed to study the effectiveness of cholinomimetic drug (pilocarpine) and cholinergic blocking drug (atropine) to blood flow -in the rabbit submaxillary gland by means of impedance rheograph. It was used that the jugular vein as a route of the drug administration and that the carotid artery to get the blood pressure by the pressure transducer (Narco Co. ). The gland was intactly exposed alone and grounded on a aluminum foil. Fifteen rabbits about 2kgs of body weight were divided to three groups, to the first group atropine of last dosage 1mg, 3mg, 5mg/kg of body weight, pilocarpine -of last dosage 0.05, 0.15, 0.25mg/kg for the second group and the third group -was given pilocarpine of last dosage 0.05, 0.15, 0.25, 0.50mg/kg after blocking -wath 2mg/kg of atropine. Two needle electrodes were inserted into the gland with a proper distance and connected continuously to the impedance rheograph, high-gain preamplifier and physiograph to obtain rheogram on the physiograph. Amplitude of experimental rheogram was compared to that of control. The results were a- follows; 1. The blood flow of submaxillary gland was not altered in atrophine group and heart rate was decreased in proportion to the concentrationa of the drug. 2. In pilocarpine group, the blood flow of submaxillary gland was increased but the heart rate was decreased in proportion to the concentration of the drug. 3. In atropine and pilocarpine group, the increase of blood flow was decreased markedly than that of pilocarpine group.
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